[media-credit id=”1″ align=”alignleft” width=”300″]Dexamethasone Coronavirus Covid-19[/media-credit]

is being called a “Major Breakthrough” based on a recent RCT in the UK. (Decadron), is an example of a glucocorticoid. Glucocorticoids are sometimes referred to corticosteroids. Other examples of glucocorticoids include Hydrocortisone, Methylprednisolone, Prednisolone, Prednisone, Betamethasone, and Triamcinolone. Glucocorticoids are a class of steroid hormones that bind to the glucocorticoid receptor in the body. Cortisol (hydrocortisone) is the glucocorticoid we naturally make in our body. It is essential for life, and it regulates or supports various cardiovascular, metabolic, and homeostatic functions. It also plays a big role in our immune system, especially when it comes to reducing certain aspects of inflammation.


This is why we use them all the time in medicine. We sometimes give these steroids for asthma, COPD, rheumatologic type diseases, and countless more diseases. Sometimes we give steroids for meningitis, and also for some forms of cancer. We give them in the early course of severe ARDS, acute respiratory distress syndrome, whether that ARDS is due to infection such pneumonia, or vaping lung injury, or whatever the cause.

[media-credit id=”1″ align=”alignleft” width=”300″]Dexamethasone Coronavirus[/media-credit]

For severe ARDS, we typically give methylprednisone, at a dose of 1 mg/kg per day. So for most people, that ends being around 80 mg per day. This is the equivalent of 15 mg of . The idea here is to suppress the cytokine storm that is taking place, meaning that massive amount of inflammation that causes lung damage and can indirectly cause damage to other organs well. Our body naturally makes cortisol in our adrenal glands, specifically, in the zona fasciculate of the adrenal cortex. The adrenal gland then secretes cortisol into the bloodstream, and travels to different tissues of the body, and then binds to the glucocorticoid receptor inside cells. It then stimulates the cell to make more anti-inflammatory proteins and reduces the number of pro-inflammatory proteins being made. But giving someone glucocorticoids (steroids) has an infection is somewhat of a tricky thing because the fear is that if you suppress the body’s immune system, it has the potential to make the infection worse. But sometimes the body’s immune system does more damage than the actual infection. For example, in cases of meningitis that is due to streptococcus or tuberculosis, we give steroids because the medical evidence shows that they have better outcomes when we do so.

Trending sekarang :
Detik-detik Puncak Gerhana Matahari Cincin di Siak

Giving someone steroids for viral pneumonia, such , is more controversial because doing so generally leads to a worse infection. With that said, if the viral pneumonia is so bad to the point of causing severe ARDS, most doctors including myself will give steroids in that situation. This is why the general medical guidelines thus far recommend against giving steroids for COVID pneumonia unless the patient has severe ARDS. We’ve been waiting for RCT to come out for steroids and , and here we are now. In March , the RECOVERY (Randomized Evaluation of thERapY) trial was one of that RCT that actually looked at several different potential treatments for , which included low-dose (a steroid treatment). This trial was done in the UK and had over 11,500 patients in it.

Trending sekarang :
Uji Coba Vaksin Disuntikkan Pada Manusia

So this trial has not been peer-reviewed of the making of this and has not been published in a journal yet. So everything I know so far is based on what has been released to the general public. In this trial, over 2100 patients were randomized to receive 6 mg once per day for ten days and were compared with over 4300 patients randomized to standard care alone. So 6 mg of is the equivalent of 32 mg of methylprednisolone, so this is about half the dose we would typically use for someone with severe ARDS.

[media-credit id=”1″ align=”alignleft” width=”300″]Dexamethasone[/media-credit]

Among the patients received standard care alone, 28-day mortality was highest in those required mechanical ventilation (41%), intermediate in those patients required oxygen only (25%), and lowest among those did not require any supplementary oxygen (13%). For patients on ventilators, reduced mortality from 41% to 28%. For patients needing supplemental oxygen, it reduced mortality from 25% to 20%. There was no benefit among those patients did not require supplemental oxygen. In other words, if someone only has a mild disease, there is no point in giving . Based on these results, 1 death would be prevented by treatment of around 8 ventilated patients, and around 25 patients requiring oxygen alone. So these preliminary results, are significant but do not mean that is a miracle drug. It’s certainly not a cure. But it does seem to help, based on these numbers. And could be of huge benefit in poorer countries with high numbers of patients, because the drug is very cheap, and is widely available.

Content Protection By

Post Disclaimer

Informasi yang terkandung dalam pos ini hanya untuk keperluan informasi umum. Informasi ini disediakan oleh Dexamethasone Coronavirus COVID-19 dan sementara kami berusaha untuk menjaga agar informasi tetap terbaru dan benar, kami tidak membuat pernyataan atau jaminan dalam bentuk apa pun, tersurat maupun tersirat, tentang kelengkapan, keakuratan, keandalan, kesesuaian, atau ketersediaan dengan menghormati situs web atau informasi, produk, layanan, atau gambar terkait yang terdapat pada pos untuk tujuan apa pun. 101 Portal Education News

Trending sekarang :
Edukasi Penyebaran Virus Corona ke Anak


Silakan masukkan komentar anda!
Silakan masukkan nama Anda di sini